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Brain and Neurodegeneration 

Yuan, J., et al., Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathway. J Surg Res, 2018. 228: p. 238-246.

Wu, X., et al., Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway. Brain Res, 2018.

Wang, H., et al., Hydrogen-Rich Saline Activated Autophagy via HIF-1alpha Pathways in Neuropathic Pain Model. Biomed Res Int, 2018. 2018: p. 4670834.

Varga, V., et al., Molecular hydrogen alleviates asphyxia-induced neuronal cyclooxygenase-2 expression in newborn pigs. Acta Pharmacol Sin, 2018.

Satoh, Y., et al., Molecular Hydrogen Prevents Social Deficits and Depression-Like Behaviors Induced by Low-Intensity Blast in Mice. J Neuropathol Exp Neurol, 2018.

Nishimaki, K., et al., Effects of Molecular Hydrogen Assessed by an Animal Model and a Randomized Clinical Study on Mild Cognitive Impairment. Curr Alzheimer Res, 2018. 15(5): p. 482-492.

Jiang, X., et al., FoxO1-mediated autophagy plays an important role in the neuroprotective effects of hydrogen in a rat model of vascular dementia. Behav Brain Res, 2018.

Imai, K., et al., Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model. Sci Rep, 2018. 8(1): p. 9221.

Huang, J.L., W.W. Liu, and X.J. Sun, Hydrogen inhalation improves mouse neurological outcomes after cerebral ischemia/reperfusion independent of anti-necroptosis. Med Gas Res, 2018. 8(1): p. 1-5.

Hou, C., et al., Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Abeta clearance. Free Radic Res, 2018: p. 1-12.

Choi, K.S., et al., Neuroprotective effects of hydrogen inhalation in an experimental rat intracerebral hemorrhage model. Brain Res Bull, 2018. 142: p. 122-128.

Ono, H., et al., Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection. J Stroke Cerebrovasc Dis, 2017.

Nishimaki, K., et al., Effects of molecular hydrogen assessed by an animal model and a

randomized clinical study on mild cognitive impairment. Curr Alzheimer Res, 2017.

Yoshii, Y., et al., Complexity of Stomach-Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice. Neurochem Res, 2017.

Yoneda, T., et al., Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption in Rats Fed a High-Fat Diet. Nutrients, 2017. 9(1).

Wen, D., et al., Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice.Neuropharmacology, 2017. 118: p. 199-208.

Shi, Y., et al., Hydrogen gas attenuates sevoflurane neurotoxicity through inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells signaling and proinflammatory cytokine release in neonatal rats.Neuroreport, 2017. 28(17): p. 1170-1175.

Murakami, Y., M. Ito, and I. Ohsawa, Molecular hydrogen protects against oxidative stress-induced SH-SY5Y neuroblastoma cell death through the process of mitohormesis. PLoS One, 2017. 12(5): p. e0176992.

Mizuno, K., et al., Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life. Med Gas Res, 2017. 7(4): p. 247-255.

Yoritaka, A., et al., Pilot study of H(2) therapy in Parkinson’s disease: A randomized double-blind placebo-controlled trial. Movement Disorders, 2013.

Matsuoka, T., et al., Hydrogen gas inhalation inhibits progression to the “irreversible” stage of shock after severe hemorrhage in rats. J Trauma Acute Care Surg, 2017.

Ma, H., et al., [Hydrogen-rich saline attenuates hyperalgesia and reduces cytokines in rats with post-herpetic neuralgia via activating autophagy]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2017. 33(2): p. 155-158.

Liu, Y., et al., Effect of hydrogen-rich water on the angiogenesis in lesion boundary brain tissue of traumatic brain injury-challenged rats. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2017. 10(3): p. 3807-3815.

Li, D. and Y. Ai, Hydrogen saline suppresses neuronal cell apoptosis and inhibits the p38 mitogenactivated protein kinasecaspase3 signaling pathway following cerebral ischemiareperfusion injury. Mol Med Rep, 2017. 16(4): p. 5321-5325.

Li, C., et al., Hydrogen-rich saline attenuates isoflurane-induced caspase-3 activation and cognitive impairment via inhibition of isoflurane-induced oxidative stress, mitochondrial dysfunction, and reduction in ATP levels. Am J Transl Res, 2017. 9(3): p. 1162-1172.

He, Y., et al., Image-guided hydrogen gas delivery for protection from myocardial ischemia-reperfusion injury via microbubbles. ACS Appl Mater Interfaces, 2017.

Gao, Q., et al., Molecular hydrogen increases resilience to stress in mice. Sci Rep, 2017. 7(1): p. 9625.

 

Zhao, M., et al., Hydrogen-rich water improves neurological functional recovery in experimental autoimmune encephalomyelitis mice. J Neuroimmunol, 2016. 294: p. 6-13.

Zhang, Y., et al., Effects of hydrogen-rich water on depressive-like behavior in mice. Sci Rep, 2016. 6: p. 23742.

 

Takaenoki, Y., et al., Neonatal exposure to sevoflurane in mice causes deficits in maternal behavior later in adulthood. Anesthesiology, 2014. 120(2): p. 403-15.

Yonamine, R., et al., Coadministration of hydrogen gas as part of the carrier gas mixture suppresses neuronal apoptosis and subsequent behavioral deficits caused by neonatal exposure to sevoflurane in mice.Anesthesiology, 2013. 118(1): p. 105-13.

Zhang, Y., et al., Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis. Neurochem Res, 2016. 41(4): p. 770-8.

Zhang, L., et al., Hydrogen has a neuroprotective effect via activation of Nrf-2/HO-1 pathway in ischemia reperfusion rat. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2016. 9(6): p. 10521-10528.

Yang, L., D. Li, and S. Chen, Hydrogen water reduces NSE, IL-6, and TNF-alpha levels in hypoxic-ischemic encephalopathy. Open Med (Wars), 2016. 11(1): p. 399-406.

Wang, X., et al., The protective effects of hydrogen on HO-1 expression in the brainafter focal cerebral ischemia reperfusion in rats. Turk J Med Sci, 2016. 46(5): p. 1534-1539.

Tian, R., et al., Hydrogen-rich water attenuates brain damage and inflammation after traumatic brain injury in rats. Brain Res, 2016. 1637: p. 1-13.

Shao, A., et al., Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-kappaB Pathway and NLRP3 Inflammasome. Mol Neurobiol, 2016. 53(5): p. 3462-3476.

Nemeth, J., et al., Molecular hydrogen affords neuroprotection in a translational piglet model of hypoxic-ischemic encephalopathy. J Physiol Pharmacol, 2016. 67(5): p. 677-689.

Li, Q., et al., Neuroprotective Effect of Hydrogen-Rich Saline in Global Cerebral Ischemia/Reperfusion Rats: Up-Regulated Tregs and Down-Regulated miR-21, miR-210 and NF-kappaB Expression. Neurochem Res, 2016. 41(10): p. 2655-2665.

Cui, J., et al., Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia-reperfusion injury in rats – A possible new hydrogen resource for clinical use. Neuroscience, 2016. 335: p. 232-41.

Chen, X., et al., [Effects of hydrogen-rich water on the expression of aquaporin 1 in the cerebral cortex of rat with traumatic brain injury]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue, 2016. 28(5): p. 460-4.

Bai, X., et al., Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice. Brain Res, 2016. 1646: p. 410-7.

Zhang, Y.G., et al., Hydrogen-rich saline promotes motor functional recovery following peripheral nerve autografting in rats. Experimental and Therapeutic Medicine., 2015. 10(2).

Yu, Y., et al., Protective effect of hydrogenrich medium against high glucoseinduced apoptosis of Schwann cells in vitro. Mol Med Rep, 2015. 12(3): p. 3986-92.

Wei, R., et al., Hydrogen Suppresses Hypoxia/Reoxygenation-Induced Cell Death in Hippocampal Neurons Through Reducing Oxidative Stress. Cell Physiol Biochem, 2015. 36(2): p. 585-98.

Takeuchi, S., et al., Hydrogen improves neurological function through attenuation of blood-brain barrier disruption in spontaneously hypertensive stroke-prone rats. BMC Neurosci, 2015. 16: p. 22.

Shao, A., et al., Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by Suppressing Inflammatory Response: Possible Involvement of NF-kappaB Pathway and NLRP3 Inflammasome. Mol Neurobiol, 2015.

Nakano, T., et al., Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury. J Clin Biochem Nutr, 2015. 57(3): p. 178-82.

Lin, C.L., et al., Hydrogen-rich water attenuates amyloid beta-induced cytotoxicity through upregulation of Sirt1-FoxO3a by stimulation of AMP-activated protein kinase in SK-N-MC cells. Chem Biol Interact, 2015. 240: p. 12-21.

Han, L., et al., Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering proteins. Brain Res, 2015.

Du, Z., et al., Three hydrogen-rich solutions protect against intestinal injury in uncontrolled hemorrhagic shock. Int J Clin Exp Med, 2015. 8(5): p. 7620-6.

Du, Z., et al., Effects of three hydrogen-rich liquids on hemorrhagic shock in rats. J Surg Res, 2015. 193(1): p. 377-82.

Chen, Y., et al., H2Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat Model of Neuropathic Pain. Inflammation, 2015. 38(5): p. 1835-46.

Zhang, L., et al., Hydrogen-rich saline controls remifentanil-induced hypernociception and NMDA receptor NR1 subunit membrane trafficking through GSK-3beta in the DRG in rats. Brain Res Bull, 2014. 106C: p. 47-55.

Wang, T., et al., Oral intake of hydrogen-rich water ameliorated chlorpyrifos-induced neurotoxicity in rats. Toxicol Appl Pharmacol, 2014.

Tomura, S., et al., Physiological effects of combination therapy of intracisternal infusion of magnesium sulfate solution and intravenous injection of hydrogen-enriched fluid in the rat. Bōei Ika Daigakkō zasshi= Journal of the National Defense Medical College, 2014. 39: p. 96-102.

Mei, K., et al., Hydrogen protects rats from dermatitis caused by local radiation. J Dermatolog Treat, 2014. 25(2): p. 182-8.

Mano, Y., et al., Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion. Free Radic Biol Med, 2014. 69: p. 324-30.

Liu, L., et al., Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis. Brain Res, 2014. 1589: p. 78-92.

Liu, F.T., et al., Molecular Hydrogen Suppresses Reactive Astrogliosis Related to Oxidative Injury during Spinal Cord Injury in Rats. CNS Neurosci Ther, 2014.

Kashiwagi, T., et al., Electrochemically reduced water protects neural cells from oxidative damage. Oxid Med Cell Longev, 2014. 2014: p. 869121.

Hong, Y., et al., Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: possible role of the Akt/GSK3beta signaling pathway. PLoS One, 2014. 9(4): p. e96212.

Dohi, K., et al., Molecular Hydrogen in Drinking Water Protects against Neurodegenerative Changes Induced by Traumatic Brain Injury. PLoS One, 2014. 9(9): p. e108034.

Cui, Y., et al., Hydrogen-rich saline attenuates neuronal ischemia-reperfusion injury by protecting mitochondrial function in rats. J Surg Res, 2014.

Zhuang, Z., et al., Nuclear factor-kappaB/Bcl-XL pathway is involved in the protective effect of hydrogen-rich saline on the brain following experimental subarachnoid hemorrhage in rabbits. J Neurosci Res, 2013. 91(12): p. 1599-608.

Shen, M.H., et al., Neuroprotective effect of hydrogen-rich saline in acute carbon monoxide poisoning. CNS Neurosci Ther, 2013. 19(5): p. 361-3.

Olah, O., et al., Delayed neurovascular dysfunction is alleviated by hydrogen in asphyxiated newborn pigs.Neonatology, 2013. 104(2): p. 79-86.

Nagatani, K., et al., Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies. Med Gas Res, 2013. 3: p. 13.

Matsumoto, A., et al., Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice. Sci Rep, 2013. 3: p. 3273.

Manaenko, A., et al., Hydrogen inhalation ameliorated mast cell-mediated brain injury after intracerebral hemorrhage in mice. Critical Care Medicine, 2013. 41(5): p. 1266-75.

Huang, G., et al., The neuroprotective effects of intraperitoneal injection of hydrogen in rabbits with cardiac arrest. Resuscitation, 2013. 84(5): p. 690-5.

Feng, Y., et al., Hydrogen-rich saline prevents early neurovascular dysfunction resulting from inhibition of oxidative stress in STZ-diabetic rats. Curr Eye Res, 2013. 38(3): p. 396-404.

Zhuang, Z., et al., Hydrogen-rich saline alleviates early brain injury via reducing oxidative stress and brain edema following experimental subarachnoid hemorrhage in rabbits. BMC Neurosci, 2012. 13: p. 47.

Zhou, J., et al., Hydrogen-rich saline reverses oxidative stress, cognitive impairment, and mortality in rats submitted to sepsis by cecal ligation and puncture. Journal of Surgical Research, 2012. 178(1): p. 390-400.

Zhan, Y., et al., Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats. Critical Care Medicine, 2012. 40(4): p. 1291-6.

Wang, W., et al., Hydrogen rich saline reduces immune-mediated brain injury in rats with acute carbon monoxide poisoning. Neurological Research, 2012. 34(10): p. 1007-15.

Spulber, S., et al., Molecular hydrogen reduces LPS-induced neuroinflammation and promotes recovery from sickness behaviour in mice. PLoS One, 2012. 7(7): p. e42078.

Ji, X., et al., Protective effects of hydrogen-rich saline in a rat model of traumatic brain injury via reducing oxidative stress. Journal of Surgical Research, 2012. 178(1): p. e9-16.

Ito, M., et al., Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats. Med Gas Res, 2012. 2(1): p. 15.

Hou, Z., et al., Hydrogen-rich saline protects against oxidative damage and cognitive deficits after mild traumatic brain injury. Brain Res Bull, 2012. 88(6): p. 560-5.

Hong, Y., et al., Beneficial effect of hydrogen-rich saline on cerebral vasospasm after experimental subarachnoid hemorrhage in rats. J Neurosci Res, 2012. 90(8): p. 1670-80.

Yan, H., et al., The neuroprotective effects of electrolyzed reduced water and its model water containing molecular hydrogen and Pt nanoparticles. BMC Proc, 2011. 5 Suppl 8: p. P69.

Wang, C., et al., Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-kappaB activation in a rat model of amyloid-beta-induced Alzheimer’s disease. Neuroscience Letters, 2011. 491(2): p. 127-32.

Ueda, Y., T. Kojima, and T. Oikawa, Hippocampal gene network analysis suggests that coral calcium hydride may reduce accelerated senescence in mice. Nutrition Research, 2011. 31(11): p. 863-72.

Sun, Q., et al., Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity. Critical Care Medicine, 2011. 39(4): p. 765-9.

Shen, L., et al., Hydrogen-rich saline is cerebroprotective in a rat model of deep hypothermic circulatory arrest.Neurochemical Research, 2011. 36(8): p. 1501-11.

Ono, H., et al., Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. A non-controlled study. Medical Gas Research, 2011. 1(1): p. 12.

Manaenko, A., et al., Hydrogen inhalation is neuroprotective and improves functional outcomes in mice after intracerebral hemorrhage. Acta Neurochir Suppl, 2011. 111: p. 179-83.

Liu, W., et al., Protective effects of hydrogen on fetal brain injury during maternal hypoxia. Acta Neurochir Suppl, 2011. 111: p. 307-11.

Kuroki, C., et al.,  Neuroprotective effects of hydrogen gas on brain in three types of stress models: A P-31-NMR and ESR study. Neuroscience Research, 2011. 71: p. E406-E406.

Kobayashi, H., et al., Effects of Hydrogen Gas in a Mouse Cold Induced Brain Injury Model. Journal of Neurotrauma, 2011. 28(5): p. A64-A64.

Hugyecz, M., et al., Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. Brain Research, 2011. 1404: p. 31-8.

Eckermann, J.M., et al., Hydrogen is neuroprotective against surgically induced brain injury. Medical Gas Research, 2011. 1(1): p. 7.

Yokoi, I., Neuroprotective effects of hydrogen gas on brain in three types of stress models: a P-31 NMR and ESR study. Neuroscience Research, 2010. 68: p. E320-E320.

Ueda, Y., A. Nakajima, and T. Oikawa, Hydrogen-Related Enhancement of In Vivo Antioxidant Ability in the Brain of Rats Fed Coral Calcium Hydride. Neurochemical Research, 2010. 35(10): p. 1510-1515.

Li, J., et al., Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer’s disease by reduction of oxidative stress. Brain Res, 2010. 1328: p. 152-161.

Ji, X., et al., Beneficial effects of hydrogen gas in a rat model of traumatic brain injury via reducing oxidative stress. Brain Research, 2010. 1354: p. 196-205.

Hong, Y., S. Chen, and J.M. Zhang, [Research advances on hydrogen therapy in nervous system diseases]. Zhejiang Da Xue Xue Bao Yi Xue Ban, 2010. 39(6): p. 638-43.

Gu, Y., et al., Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-Accelerated Mice. Journal of Clinical Biochemistry and Nutrition, 2010. 46(3): p. 269-276.

Domoki, F., et al., Hydrogen is Neuroprotective and Preserves Cerebrovascular Reactivity in Asphyxiated Newborn Pigs. Pediatric Research, 2010. 68(5): p. 387-392.

Bari, F., et al., Inhalation of Hydrogen Gas Protects Cerebrovascular Reactivity Against Moderate but Not Severe Perinatal Hypoxic Injury in Newborn Piglets. Stroke, 2010. 41(4): p. E323-E323.

Nagata, K., et al., Consumption of Molecular Hydrogen Prevents the Stress-Induced Impairments in Hippocampus-Dependent Learning Tasks during Chronic Physical Restraint in Mice. Neuropsychopharmacology, 2009. 34(2): p. 501-508.

Kuroki, C., et al., Neuroprotective effects of hydrogen gas on brain in three types of stress models: alpha P-31-NMR study. Neuroscience Research, 2009. 65: p. S124-S124.

Fujita, K., et al., Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease. PLoS One, 2009. 4(9): p. e7247.

Fu, Y., et al., Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease. Neuroscience Letters, 2009. 453: p. 81–85.

Sato, Y., et al., Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice. Biochem Biophys Res Commun, 2008. 375(3): p. 346-350.

Kashiwagi, T., et al., Suppression of Oxidative Stress-Induced Apoptosis of Neuronal Cells by Electrolyzed-Reduced Water. Animal Cell Technology Meets Genomics, 2005. 2: p. 257-260.

Credit for this list given to the Molecular Hydrogen Institute.



Molecular hydrogen (H₂) is a unique antioxidant. H₂ eliminates only the most harmful free radicals, reduces oxidative stress and puts the body in balance.

Due to its small size and bioavailability, it easily crosses cell membranes, the blood brain-barrier and accesses parts of the cell that other antioxidants are too large to reach. H₂ is the perfect antioxidant mediator, anti-inflammatory, and anti-apoptotic molecule without effecting cell signaling.

 

Molecular Hydrogen:

The Most Powerful Antioxidant

and Anti-Inflammatory

  • Improve cognitive function

  • Reduce inflammation 

  • Promote cellular health

  • Increase energy

  • Have better skin health and tone

  • Improve sleeping patterns

  • Enhance athletic performance + decrease recovery time

  • Support healthy weight management

  • Hydrate at the cellular level

  • Prevent hangovers

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