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Diabetes and Obesity

Zhang, X., et al., Subcutaneous injection of hydrogen gas is a novel effective treatment for type 2 diabetes. J Diabetes Investig, 2018. 9(1): p. 83-90.

Korovljev, D., et al., Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women. Ir J Med Sci, 2017.

Hou, C., et al., Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer. Biochem Pharmacol, 2016. 103: p. 85-97.

Zong, C., et al., Cigarette smoke exposure impairs reverse cholesterol transport which can be minimized by treatment of hydrogen-saturated saline. Lipids Health Dis, 2015. 14: p. 159.

Song, G., et al., Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. Journal of Lipid Research, 2013. 54(7): p. 1884-93.

Jiang, H., et al., Hydrogen-rich medium suppresses the generation of reactive oxygen species, elevates the Bcl-2/Bax ratio and inhibits advanced glycation end product-induced apoptosis. Int J Mol Med, 2013. 31(6): p. 1381-7.

Iio, A., et al., Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating CD36 expression in HepG2 cells. Medical Gas Research, 2013. 3(1): p. 6.

Ignacio, R.M., et al., Anti-obesity effect of alkaline reduced water in high fat-fed obese mice. Biol Pharm Bull, 2013. 36(7): p. 1052-9.

He, B., et al., Protection of oral hydrogen water as an antioxidant on pulmonary hypertension. Mol Biol Rep, 2013. 40(9): p. 5513-21.

Fan, M., et al., Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin induced diabetic rat model. Journal of Urology, 2013. 190(1): p. 350-6.

Chen, Y., et al., Hydrogen-rich saline attenuates vascular smooth muscle cell proliferation and neointimal hyperplasia by inhibiting reactive oxygen species production and inactivating the Ras-ERK1/2-MEK1/2 and Akt pathways. International Journal of Molecular Medicine, 2013. 31(3): p. 597-606.

Baek, D.-H., Antibacterial Activity of Hydrogen-rich Water Against Oral Bacteria.

Amitani, H., et al., Hydrogen Improves Glycemic Control in Type1 Diabetic Animal Model by Promoting Glucose Uptake into Skeletal Muscle. PLoS One, 2013. 8(1).

Zong, C., et al., Administration of hydrogen-saturated saline decreases plasma low-density lipoprotein cholesterol levels and improves high-density lipoprotein function in high-fat diet-fed hamsters. Metabolism, 2012. 61(6): p. 794-800.

Zheng, H. and Y.S. Yu, Chronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive rats. Biochemical Pharmacology, 2012. 83(9): p. 1269-77.

Yu, Y.S. and H. Zheng, Chronic hydrogen-rich saline treatment reduces oxidative stress and attenuates left ventricular hypertrophy in spontaneous hypertensive rats. Mol Cell Biochem, 2012. 365(1-2): p. 233-42.

Wang, Q.J., et al., Therapeutic effects of hydrogen saturated saline on rat diabetic model and insulin resistant model via reduction of oxidative stress. Chin Med J (Engl), 2012. 125(9): p. 1633-7.

Tanabe, H., et al., Suppressive Effect of High Hydrogen Generating High Amylose Cornstarch on Subacute Hepatic Ischemia-reperfusion Injury in Rats. Biosci Microbiota Food Health, 2012. 31(4): p. 103-8.

Song, G., et al., Hydrogen decreases athero-susceptibility in apolipoprotein B-containing lipoproteins and aorta of apolipoprotein E knockout mice. Atherosclerosis, 2012. 221(1): p. 55-65.

Nishioka, S., et al., Effect of hydrogen gas inhalation on lipid metabolism and left ventricular remodeling induced by intermittent hypoxia in mice. European Heart Journal, 2012. 33: p. 794-794.

Kawai, D., et al., Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice. Hepatology, 2012. 56(3): p. 912-21.

Fan, M., et al., Protective Effects of Hydrogen-Rich Saline Against Erectile Dysfunction in a Streptozotocin Induced Diabetic Rat Model. J Urol, 2012.

Ekuni, D., et al., Hydrogen-rich water prevents lipid deposition in the descending aorta in a rat periodontitis model. Arch Oral Biol, 2012. 57(12): p. 1615-22.

Yu, P., et al., Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage. Biochemical and Biophysical Research Communications, 2011. 409(2): p. 350-5.

Yang, X., et al., Protective effects of hydrogen-rich saline in preeclampsia rat model. Placenta, 2011. 32(9): p. 681-6.

Wang, Y., et al., Protective effects of hydrogen-rich saline on monocrotaline-induced pulmonary hypertension in a rat model. Respir Res, 2011. 12: p. 26.

Song, G., et al., H2 inhibits TNF-alpha-induced lectin-like oxidized LDL receptor-1 expression by inhibiting nuclear factor kappaB activation in endothelial cells. Biotechnology Letters, 2011. 33(9): p. 1715-22.

Shirahata, S., et al., Anti-diabetes effect of water containing hydrogen molecule and Pt nanoparticles. BMC Proc, 2011. 5 Suppl 8: p. P18.

Nakai, Y., et al., Hepatic oxidoreduction-related genes are upregulated by administration of hydrogen-saturated drinking water. Bioscience, Biotechnology, and Biochemistry, 2011. 75(4): p. 774-6.

Li, Y., et al., Suppressive effects of electrolyzed reduced water on alloxan-induced apoptosis and type 1 diabetes mellitus. Cytotechnology, 2011. 63(2): p. 119-31.

Kamimura, N., et al., Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice. Obesity, 2011.

Hashimoto, M., et al., Effects of hydrogen-rich water on abnormalities in a SHR.Cg-Leprcp/NDmcr rat – a metabolic syndrome rat model. Medical Gas Research, 2011. 1(1): p. 26.

Nakao, A., et al., Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome-An Open Label Pilot Study. Journal of Clinical Biochemistry and Nutrition, 2010. 46(2): p. 140-149.

Chen, C.H., et al., Hydrogen Gas Reduced Acute Hyperglycemia-Enhanced Hemorrhagic Transformation in a Focal Ischemia Rat Model. Neuroscience, 2010. 169(1): p. 402-414.

Abe, M., et al., Suppressive Effect of ERW on Lipid Peroxidation and Plasma Triglyceride Level, in Animal Cell Technology: Basic & Applied Aspects, S. Netherlands, Editor. 2010. p. 315-321.

Chao, Y.C. and M.T. Chiang, Effect of alkaline reduced water on erythrocyte oxidative status and plasma lipids of spontaneously hypertensive rats. Taiwanese Journal of Agricultural Chemistry and Food Science, 2009. 47(2): p. 71-72.

Ohsawa, I., et al., Consumption of hydrogen water prevents atherosclerosis in apoliporotein E knockout mice.Biochem Biophys Res Commun, 2008. 377(4): p. 1195-8.

Kajiyama, S., et al., Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutrition Research, 2008. 28: p. 137–143.

Kim, M.J., et al., Preservative effect of electrolyzed reduced water on pancreatic beta-cell mass in diabetic db/db mice. Biol Pharm Bull, 2007. 30(2): p. 234-6.

Yeunhwa GU, K.O., Taigo FUj, Yuka ITOKAWA, et al., Anti Type 2 Diabetic Effect and Anti-oxidation Effect in Active Hydrogen Water Administration KK-Ay Mice. Medicine and Biology, 2006. 150(11): p. 384-392.

Kim, M.J. and H.K. Kim, Anti-diabetic effects of electrolyzed reduced water in streptozotocin-induced and genetic diabetic mice. Life Sci, 2006. 79(24): p. 2288-92.

Jin, D., et al., Anti-diabetic effect of alkaline-reduced water on OLETF rats. Biosci Biotechnol Biochem, 2006. 70(1): p. 31-7.

GU, H.Y., et al., Anti-oxidation Effect and Anti Type 2 Diabetic Effect in Active Hydrogen Water Medicine and Biology, 2006. 150(11): p. 384-392.

Dan, J., et al., Effect of mineral induced alkaline reduced water on sprague-dawley rats fed on a high fat diet. Exp. Biomed. Sci., 2006. 12: p. 1-7.

Li, Y.-P., Teruya, K., Katakura, Y., Kabayama, S., Otsubo, K.,Morisawa, S., et al, Effect of reduced water on the apoptotic cell death triggered by oxidative stress in pancreatic b HIT-T15 cell. Animal cell technology meets genomics, 2005: p. 121-124.

Kim, H.-W., Alkaline Reduced Water produced by UMQ showed Anti-cancer and Anti-diabetic effect. published online at http://www.korea-water.com/images/e_q.pdf 2004.

Hamaskai, T., et al., The suppressive effect of electrolyzed reduced water on lipid peroxidation. Animal Cell Technology: Basic & Applied Aspects, 2003. 13: p. 381-385.

Chiasson, J.L., et al., Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA, 2003. 290(4): p. 486-94.

Li, Y., et al., Protective mechanism of reduced water against alloxan-induced pancreatic beta-cell damage: Scavenging effect against reactive oxygen species. Cytotechnology, 2002. 40(1-3): p. 139-49.

Shirahata, S., Anti-oxidative water improves diabetes.

Oda, M., et al., Electrolyzed and natural reduced water exhibit insulin-like activity on glucose uptake into muscle cells and adipocytes. Animal Cell Technology: Products from Cells, Cells as Products, 2000: p. 425-427.

Nelson, D., et al., Effect of electrolyzed water intake on lifespan of autoimmune disease prone mice. Faseb Journal, 1998. 12(5): p. A794-A794.

Yokoyama, J.-m.K.a.K., Effects of alkaline ionized water on spontaneously diabetic GK-rats fed sucrose. J. of Lab. Anim Sa, 1997. 13(2): p. 187-190.

Darnaud, C., [Indications for alkaline mineral water cure in diabetes mellitus]. Toulouse Med, 1951. 52(5): p. 277-84.

Credit for this list given to the Molecular Hydrogen Institute.



Molecular hydrogen (H₂) is a unique antioxidant with the potential to revolutionize the self-care industry. By boosting your intake of this ordinary element (made extraordinary through our availability technology), you can reap multiple benefits. In the body, H₂ molecular hydrogen eliminates only the most harmful free radicals, thereby reducing oxidative stress and allowing the body to maintain optimal functionality and achieve balance.

Due to its extremely small size and superb bioavailability, a hydrogen supplement easily and rapidly travels far and wide throughout the body. It’s able to cross cell membranes, penetrating well into the cytoplasm of your cells and mopping up rogue free radicals. H₂ is a molecular hydrogen antioxidant that also crosses the blood brain-barrier with ease, and accesses parts of the cell that other antioxidants are incapable of reaching.

At Vital Reaction, our H₂ supplement is a natural antioxidant and anti-inflammatory molecule, which works rapidly to promote wellness and balance within the body, without adversely affecting cell signaling.

Free Radicals Cannot Be Eliminated — But They Can Be Limited

Free radicals are generated naturally — and inevitably — deep within our cells. They are a natural byproduct of the fundamental processes that enable us to generate energy from the foods we consume. There’s a reason we say we are “burning calories.” This energy-generating process literally uses oxygen to “burn” the molecules obtained from the food we ingest for fuel.

This process generates free radicals. In some instances, the immune system uses these highly reactive and potentially damaging molecules to attack foreign invaders and maintain robust immune function — so free radicals are not entirely negative.

As always, though, balance is everything. Many lifestyle activities — ranging from inactivity, to consuming fried foods, to avoiding fresh fruits and vegetables, to breathing polluted air — can affect one’s balance of antioxidants and free radicals.

Molecular Hydrogen Tablets and Inhalation Machines From Vital Reaction

Consumable H₂ molecular hydrogen from Vital Reaction affords you the opportunity to boost your supply of one of nature’s most versatile, potent antioxidants. It’s the natural way to combat inflammation and promote healthful balance.

Vital Reaction offers high-quality molecular hydrogen products, including tablets and hydrogen inhalers. Tablets can be dissolved in drinking water for a quick boost, as part of your daily health regimen. With Vital Reaction, you get the most hydrogen per serving of any product on the market.

Molecular Hydrogen:

The most powerful hydrogen antioxidant and anti-inflammatory can offer the following benefits:

  • Improve cognitive function

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  • Have better skin health and tone

  • Improve sleeping patterns

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  • Hydrate at the cellular level

  • Prevent hangovers

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