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Molecular Hydrogen and Athletes

By Adam Trainor May 15, 2019

Molecular Hydrogen is well known to have powerful antioxidant, anti-inflammatory and anti-apoptotic properties.

Molecular Hydrogen delivers some pretty shocking results that can help athletes train more optimally. This post goes over:

  ○  Free radicals’ adverse effects on training

  ○  Positive effects of Molecular Hydrogen on hardcore athletes

  ○  How Molecular Hydrogen increases the benefits of exercise

Let’s dive in!

Production of Free Radicals

Formation of Free Radicals


As with most applications for molecular hydrogen, we have to start with a discussion of free radicals, particularly Reactive Oxygen Species (ROS for short).
ROS are created in many ways- due to a variety of external environmental exposures, as well as a consequence of our own metabolism. If we look at the world around us, it makes sense that when you burn fuel for energy, you create unwanted waste products.
Think about the exhaust produced by your car.
Metabolism byproducts
Just as exhaust is produced when our cars burn gasoline, think of ROS are the unwanted byproduct of the process by which our bodies metabolize macronutrients for fuel.
It’s not as black and white as with car exhaust, as ROS can sometimes serve important and beneficial purposes (more on this to come), but the analogy is close enough to provide some context.
Antioxidants are molecules that counteract and neutralize these free radicals. Our body is constantly producing natural antioxidants to maintain a balance with the ROS produced by ongoing energy metabolism.
Molecular hydrogen is a powerful antioxidant. What makes molecular hydrogen so great is that it:
  • Is an antioxidant that selectively targets the WORST free radical, the hydroxyl radical. This is particularly important because our bodies don’t actually have any natural countermeasure to this harmful molecule.

  • Remember how we said metabolism isn’t black and white? Some ROS serve important roles as cell signalling molecules. Because it’s selective, molecular hydrogen leaves these beneficial ROS alone.

  • Molecular hydrogen works in part by ramping up our own production of natural antioxidants. It works at the genetic level to up-regulate transcription of powerful antioxidants, like superoxide dismutase and glutathione peroxidase, through activation of the NRF2 pathway.

Exercise and Reactive Oxygen Species (ROS)

Ok. So what does all this have to do with athletes?
Well, if ROS are a byproduct of normal metabolism, what happens when you kick things into high gear?
During exercise, we need to burn a lot more fuel, which results in...drum roll...a lot more ROS produced as a byproduct.
Reactive oxygen species during exercise
During intense exercise various metabolic waste products start to build up in our systems, waste products like lactate and a number of free radicals. We can metabolize and buffer these up to a point, but eventually they overwhelm our system (unless you’re blessed with freaky genetics like ultrarunner Dean Karnazes...)
This is part of the process by which our body self-regulates. The presence of these metabolites is part of what triggers our brain to make us feel fatigued and want to stop.
The formula for fitness is roughly as follows:
Fitness = Training x Time + Recovery
So if we could increase any of these variables...
  • How hard you can work while training

  • Length of time for which you are able to train

  • Amount of recovery in a given timeframe

...we could see a big increase in fitness.
Since part of what limits our effort and intensity during exercise is the production of ROS, in theory, a powerful antioxidant could let you train harder for longer, which will result in improved fitness.
Fortunately, we don’t have to rely on theory. A number of studies have explored the effects of molecular hydrogen and athletes. So what did they find?

Research on Molecular Hydrogen and Athletes

Athlete molecular hydrogen research


In studies looking at subjects ranging from weekend warriors to elite athletes molecular hydrogen supplementation resulted in…
Not too shabby for a tiny molecule.
But wait a minute, I hear you exercise physiologists saying, don’t antioxidants blunt the effects of training?
That’s a great question.
The idea of supplementation with antioxidants to improve athletic performance is not new.
What the research began to show is that taking exogenous antioxidants like Vitamin C actually impaired athletes’ performance and fitness.
The reason for this is because most antioxidants (like Vitamin C) are not selective. They indiscriminately target all ROS.
The key to this decrease in performance is a concept called hormesis. Hormesis is the foundational principle of pretty much any kind of training. In a nutshell, it’s the idea that if we stress a system and then give it time to recover, it will rebuild stronger than it was before.
Turns out, one of the triggers of the hormetic response to exercise is the presence of free radicals. So an indiscriminate antioxidant that wipes out ALL of the free radicals will prevent some of the hormetic response to training. Remember, we said that sometime ROS play a beneficial role as cell signalling molecules.
If only there were a selective antioxidant with sniper-like targeting that only went after the “bad” free radicals, and left the ones that we need for cell signalling alone…
Well it turns out that molecular hydrogen does exactly that.
Molecular hydrogen is uniquely selective, and only targets ROS that would otherwise be harmful, without interfering with beneficial ROS that serve important cellular functions. This makes it the ideal antioxidant supplement for athletes.
But it gets even better…

NRF2...A Master Regulatory Pathway

One of the important ways that molecular hydrogen seems to work is by activating one of our body’s master antioxidant and anti-inflammatory regulatory pathways, the NRF2 pathway. Basically it turns on genes that up-regulate the production of endogenous antioxidants and anti-inflammatory cell mediators.
Keap1 NRF2 regulation system
AND, just as molecular hydrogen is selective when it comes to targeting, it’s selective when it comes to activation of the NRF2 pathway.
It seems to only initiate beneficial gene transcription when we really need it, which is good, because having it switched “on” all the time isn’t so great either.
Finally, recent findings suggest that NRF2 activation is actually necessary to get benefits of exercise.
So in molecular hydrogen we have a supplement that helps facilitate NRF2 activation, lets you work out harder AND recover faster WITHOUT the negative side effects of other antioxidants.
Like I said, not too shabby for such a tiny molecule.
If you’d like to see if Vital Reaction Molecular Hydrogen can impact your training today, shop here.
Have you experimented with molecular hydrogen in your training? Please share your experiences (or questions!) in the comments below!

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In the body, H2 molecular hydrogen eliminates only the most harmful free radicals, thereby reducing oxidative stress and allowing the body to maintain optimal functionality and achieve balance.

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Moleculary Hydrogen, a unique antioxidant

Molecular hydrogen (H₂) is a unique antioxidant with the potential to revolutionize the self-care industry. By boosting your intake of this ordinary element (made extraordinary through our availability technology), you can reap multiple benefits. In the body, H₂ molecular hydrogen eliminates only the most harmful free radicals, thereby reducing oxidative stress and allowing the body to maintain optimal functionality and achieve balance.

Due to its extremely small size and superb bioavailability, a hydrogen supplement easily and rapidly travels far and wide throughout the body. It’s able to cross cell membranes, penetrating well into the cytoplasm of your cells and mopping up rogue free radicals. H₂ is a molecular hydrogen antioxidant that also crosses the blood brain-barrier with ease, and accesses parts of the cell that other antioxidants are incapable of reaching.

At Vital Reaction, our H₂ supplement is a natural antioxidant and anti-inflammatory molecule, which works rapidly to promote wellness and balance within the body, without adversely affecting cell signaling.

Free Radicals Cannot Be Eliminated — But They Can Be Limited

Free radicals are generated naturally — and inevitably — deep within our cells. They are a natural byproduct of the fundamental processes that enable us to generate energy from the foods we consume. There’s a reason we say we are “burning calories.” This energy-generating process literally uses oxygen to “burn” the molecules obtained from the food we ingest for fuel.

This process generates free radicals. In some instances, the immune system uses these highly reactive and potentially damaging molecules to attack foreign invaders and maintain robust immune function — so free radicals are not entirely negative.

As always, though, balance is everything. Many lifestyle activities — ranging from inactivity, to consuming fried foods, to avoiding fresh fruits and vegetables, to breathing polluted air — can affect one’s balance of antioxidants and free radicals.

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